Publications

Hui Tang, P. Xie, J. Ahn, M. Choi, J. Fan, S. Chen, Y. Zhang, B. Zhang (2026). Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance. Nature Cancer.

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Maya Walker, Bin Hu, Shi-Yuan Cheng, Xiao Song (2026). Stepwise Protocol for Alternative Splicing Analysis in Single-Cell SMART-Seq2 RNA-Seq Data. Bio-protocol.

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Xiaoyu Yu, Xiao Song, Schäfer RA, Meng Q, Deanna Tiek, Runxin Wu, Qiang He, Maya Walker, Yang R, Cao Q, Bin Hu, Shi-Yuan Cheng (2026). Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced QKI isoforms. Neuro-Oncology.

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Xiaoyu Yu, Xiao Song, Schäfer RA, Meng Q, Deanna Tiek, Runxin Wu, Qiang He, Maya Walker, Yang R, Cao Q, Bin Hu, Shi-Yuan Cheng (2026). An EGFR Co-Amplified and De Novo Long Noncoding RNA HELDR Promotes Glioblastoma Malignancy through KAT7-Driven Gene Programs. Nature Cell Biology.

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Deanna Tiek, Xiao Song, Xiaoyu Yu, Roxana Iglesia, Runxin Wu, Angela Catezone, Katie McCourtney, Jessica Walshon, Christopher Horbinski, Parham Jamshidi, Rachel Castellani, Ralph Vassar, Jason Miska, Bin Hu, Shi-Yuan Cheng (2026). Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds. Neuro-Oncology.

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H. Ali, N. Zhou, L. Chen, L. Van Hijfte, R. Tulaiha, V. Karri, Y. Zhou, K. Habashy, V. Arrieta, K. S. Kim, J. Duffy, R. Yeeravalli, D. M. Tiek, Xiao Song, S. Mishra, C. Horbinski, C. Lee-Chang, A. Ahmed, L. Wang, D. H. Heiland, A. M. Sonabend, C. Dmello (2026). YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas. Neuro-Oncology.

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Xiao Song, Deanna Tiek, Minghui Lu, Xiaoyu Yu, Runxin Wu, Maya Walker, Qiang He, David Sisbarro, Bin Hu, Shi-Yuan Cheng (2025). A Single-Cell Atlas of RNA Alternative Splicing in the Glioma-Immune Ecosystem. Genome Biology.

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Runxin Wu, Shengbin Yu, Anna Bi, Deanna Tiek, Ke Yu, H. Xiong, Q. Shi, Z. Mo, Xiaoyu Yu, Xiao Song (2025). Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer. Cancer Letters.

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Xiaoyu Yu, Xiao Song, Deanna Tiek, Runxin Wu, Maya Walker, Christopher Horbinski, Bin Hu, Shi-Yuan Cheng (2025). Targeting PDGFRA-SHP2 Signaling Enhances Radiotherapy in IDH1-Mutant Glioma. Neuro-Oncology.

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J. Ahn, P. Xie, S. Chen, G. Shi, J. Fan, M. Zhang, Hui Tang, A. R. Zuckerman, D. Fang, Y. Wan, T. M. Kuzel, Y. Zhang, B. Zhang (2025). 4-1BB stimulation with concomitant inactivation of adenosine A2B receptors enhances CD8+ T cell antitumor response. J Clin Invest.

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O. Anczukow, F. H. Allain, B. L. Angarola, D. L. Black, A. N. Brooks, C. Cheng, A. Conesa, E. Crosse, I. Eyras, E. Guccione, S. X. Lu, K. M. Neugebauer, P. Sehgal, Xiao Song, Z. Tothova, J. Valcarcel, K. M. Weeks, G. W. Yeo, A. Thomas-Tikhonenko (2024). Steering research on mRNA splicing in cancer towards clinical translation. Nature Reviews Cancer.

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Xiao Song, Deanna Tiek, Shinichi Miki, Tao Huang, Minghui Lu, Anish Goenka, R. Iglesia, Xiaoyu Yu, Runxin Wu, Maya Walker, Cheng Zeng, H. Shah, Sharon H. S. Weng, A. Huff, W. Zhang, T. Koga, C. Hubert, Christopher M. Horbinski, Frank B. Furnari, Bin Hu, Shi-Yuan Cheng (2024). RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma. Journal of Clinical Investigation.

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Hui Tang, M. Zaroudi, Y. Zhu, A. Cheng, L. Qin, B. Zhang, Y. Liu (2023). Toroidal-spiral particles as a CAR-T cell delivery device for solid tumor immunotherapy. J Control Release.

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Anish Goenka, Xiao Song, Deanna Tiek, R. Iglesia, Minghui Lu, Cheng Zeng, Christopher Horbinski, W. Zhang, Bin Hu, Shi-Yuan Cheng (2023). Oncogenic long noncoding RNA LINC02283 enhances PDGF receptor A-mediated signaling and drives glioblastoma tumorigenesis. Neuro-Oncology.

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Mei-Ann Sun, Rong Yang, Hong Liu, W. Wang, Xiao Song, Bin Hu, Shi-Yuan Cheng (2023). Repurposing Clemastine to Target Glioblastoma Cell Stemness. Cancers.

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Cheng Zeng, Xiao Song, Z. Zhang, Q. Cai, J. Cai, Christopher Horbinski, Bin Hu, Shi-Yuan Cheng, W. Zhang (2023). Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis. Acta Neuropathologica Communications.

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Anish Goenka, Deanna Tiek, Xiao Song, Tao Huang, Bin Hu, Shi-Yuan Cheng (2022). The Role of Non-Coding RNAs in Glioma. Biomedicines.

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Deanna Tiek, Xiao Song, Xiaoyu Yu, Bin Hu, Shi-Yuan Cheng (2022). Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas. Science Advances.

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R. P. Iglesia, M. B. Prado, R. N. Alves, M. I. M. Escobar, C. F. L. Fernandes, A. C. S. Fortes, M. C. S. Souza, J. P. A. De Araujo, J. Tiek, Anish Goenka, Xiao Song (2022). Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression. Frontiers in Cell and Developmental Biology.

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Anish Goenka, Deanna Tiek, Xiao Song, Tao Huang, Bin Hu, Shi-Yuan Cheng (2021). The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma. Cells.

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Tao Huang, Y. Yang, Xiao Song, X. Wan, B. Wu, N. Sastry, Christopher Horbinski, C. Zeng, Deanna Tiek, Anish Goenka, F. Liu, C. W. Brennan, J. A. Kessler, R. Stupp, I. Nakano, E. P. Sulman, R. Nishikawa, C. D. James, W. Zhang, W. Xu, Bin Hu, Shi-Yuan Cheng (2021). PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Molecular Cell.

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N. G. Sastry, X. Wan, T. Huang, A. A. Alvarez, Xiao Song, C. D. James, Christopher Horbinski, C. W. Brennan, I. Nakano, Bin Hu, Shi-Yuan Cheng (2020). LY6K promotes glioblastoma tumorigenicity via CAV-1-mediated ERK1/2 signaling enhancement. Neuro-Oncology.

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Tao Huang, Xiao Song, D. Xu, Deanna Tiek, Anish Goenka, B. Wu, N. Sastry, Bin Hu, Shi-Yuan Cheng (2020). Stem cell programs in cancer initiation, progression, and therapy resistance. Theranostics.

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Xiao Song, X. Wan, T. Huang, C. Zeng, N. Sastry, B. Wu, C. D. James, Christopher Horbinski, I. Nakano, W. Zhang, Bin Hu, Shi-Yuan Cheng (2019). SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes. Cancer Research.

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T. Huang, X. Wan, A. A. Alvarez, Xiao Song, Y. Yang, N. Sastry, Shi-Yuan Cheng (2019). MIR93 (microRNA-93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy. Autophagy.

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Wang Y, Xiao Song, Zheng Y, Liu Z, Li Y, Qian X, Pang X, Zhang Y, Yin Y (2018). Cancer-testis Antigen MAGEA3 Interacts with STAT1 and Remodels the Tumor Microenvironment. International Journal of Medical Sciences.

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Xiao Song, C. Guo, Y. Zheng, Y. Wang, Z. Jin, Y. Yin (2018). Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells. BMC Cancer.

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Tao Huang, Xiao Song, Y. Yang, X. Wan, A. A. Alvarez, N. Sastry, H. Feng, Bin Hu, Shi-Yuan Cheng (2018). Autophagy and Hallmarks of Cancer. Critical Reviews in Oncogenesis.

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T. Huang, Xiao Song, Y. Yang, X. Wan, A. A. Alvarez, N. Sastry, H. Feng, Bin Hu, Shi-Yuan Cheng (2017). MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell.

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Z. P, Y. Wang, Xiao Song, Y. Zheng, Y. Liu, Y. Li, Y. Qian, X. Pang, Y. Zhang, Y. Yin (2017). Cancer-testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells. Molecular Medicine Reports.

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Xiao Song, W. Song, Y. Wang, J. Wang, Y. Li, X. Qian, X. Pang, Y. Zhang, Y. Yin, Hui Tang (2017). The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling. Oncogene.

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X. Qin, L. Lin, L. Cao, X. Zhang, Xiao Song, J. Hao, Y. Zhang, R. Wei, X. Huang, J. Lu (2017). Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis. Scientific Reports.

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J. Wang, Xiao Song, C. Guo, Y. Wang, Y. Yin (2016). Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells. Cancer Science.

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Hui Tang, J. Zhang, X. Sun, X. Qian, Y. Zhang, R. Jin (2016). Thymic DCs derived IL-27 regulates the final maturation of CD4+ SP thymocytes. Sci Rep.

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Xiao Song, W. Song, Y. Wang, J. Wang, Y. Li, X. Qian, X. Pang, Y. Zhang, Y. Yin (2016). MicroRNA-874 Functions as a Tumor Suppressor by Targeting Cancer/Testis Antigen HCA587/MAGE-C2. Journal of Cancer.

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L. Zhang, J. Chen, Xiao Song, W. Wen, Y. Li, Y. Zhang, Y. Yin (2015). Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer.

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J. Hao, Xiao Song, J. Wang, C. Guo, Y. Li, B. Li, Y. Zhang, Y. Yin (2015). Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget.

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C. Liu, H. C. Wang, S. Yu, R. Jin, Hui Tang, Y. F. Liu, Q. Ge, X. H. Sun, Y. Zhang (2014). Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol.

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C. Liu, R. Jin, H. C. Wang, Hui Tang, Y. F. Liu, X. P. Qian, S. Y. Sun, Q. Ge, X. H. Sun, Y. Zhang (2013). Id1 expression promotes peripheral CD4+ T cell proliferation and survival upon TCR activation without co-stimulation. BBRC.

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C. Liu, R. Jin, H. C. Wang, Hui Tang, Y. F. Liu, X. P. Qian, S. Y. Sun, Q. Ge, X. H. Sun, Y. Zhang (2013). Homeostatic Properties and Phenotypic Maturation of Murine CD4+ Pre-Thymic Emigrants in the Thymus. PLoS One.

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L. Zhang, J. Chen, Xiao Song, W. Wen, Y. Li, Y. Zhang, Y. Yin (2013). Cancer-testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. Oncology Research.

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F. Luo, Xiao Song, Y. Zhang, Y. Chu (2011). Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity. International Immunopharmacology.

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